ea0041gp152 | Pituitary - Clinical | ECE2016
Buning Jorien Werumeus
, van Faassen Martijn
, Brummelman Pauline
, Dullaart Robin P F
, van den Berg Gerrit
, van der Klauw Melanie M
, Kerstens Michiel N
, Kobold Anneke C Muller
, Kema Ido P
, Wolffenbuttel Bruce H R
, van Beek Andre P
Background: Patients with secondary adrenal insufficiency show increased risk of cardiovascular disease. Higher doses of glucocorticoid replacement are related to an unfavourable metabolic profile. In the absence of randomized controlled trials assessing the effect of hydrocortisone dose on haemodynamics and blood pressure regulation, we determined effects of a higher vs a lower glucocorticoid replacement dose on blood pressure, the renin-angiotensin-aldosterone system (RAAS) ...